Plasma and serum are derived from the liquid portion of the blood, however the difference between plasma and serum is quite obvious. Read on to find out how they differ. Serum and Plasma difference with tabular form
Blood is a fluid connective tissue that travels throughout the body carrying necessary nutrients, oxygen, and metabolic waste. It also participates in the regulation of body temperature and pH levels by interacting with acids and bases.
Plasma and serum can be separated by centrifugation of blood on the basis of weight, size, and density. Serum is the fluid that is obtained after allowing the blood to clot, while plasma is obtained after treating the blood with anticoagulant compounds.
Serum and plasma are obtained from the liquid portion of the blood that is obtained when cells are collected. However, there is a notable difference between plasma and serum. Serum is the fluid that remains after blood clotting. Whereas, plasma is the liquid that remains when anticoagulant is added to prevent clotting.
Below are the important differences between plasma and serum:
Plasma | Serum |
Straw-colored transparent liquid portion of blood. | An undiluted fluid, the extracellular portion of blood. |
It is composed of serum and clotting factor. | It is the part of the blood that lacks clotting factor. |
It is acquired after centrifuging blood with the anticoagulant. | It is acquired after centrifuging coagulated blood. |
Anticoagulant is required to obtain plasma from the blood sample. | Anticoagulant is not required to separate serum from blood sample. |
It consists of 55% of the total blood volume. | Lower volume compared to plasma. |
Comparatively easier and less time is required to separate plasma from blood sample. | Difficult to separate serum from blood sample. It is a very time consuming process. |
Contains fibrinogen. | It lacks fibrinogen. |
It consists of 92% water with proteins, salts, lipids and glucose. | It consists of 90% water with dissolved hormones, proteins, minerals and carbon dioxide. |
It has a density of 1.025 g / ml | It has a density of 1,024 g / ml. |
It has a long shelf life. It can be kept for up to ten years. | It has a short shelf life. It can only be kept for a few months. |
Plasma is the main medium for the transport of excretory products. | An important source of electrolytes. |
Cells are freely suspended in plasma. | Cells stick together by forming clots. |
Plasma is the medium of the blood in which there are different types of blood cells. Red blood cells, white blood cells, and other blood components are suspended in the plasma.
Serum is the liquid or undiluted part of the blood that lacks clotting factors. Therefore, it is formed after blood clotting. The serum helps in the diagnosis of diseases such as blood pressure, sugar, cholesterol, etc.
Plasma contains the most widely used anticoagulant heparin. It acts through a complex that it forms with antithrombin-III. Antithrombin III is a protein that prevents blood clotting.
Serum is the plasma from which clotting factors have been removed.
Plasma is the translucent part of the blood that is not red blood cells, white blood cells, platelets, and other cellular components. It helps blood clot and is made up of 90% water.
Collecting plasma is time consuming. It takes about an hour to collect plasma from the body. Blood is drawn from the body with the help of a needle placed in the arm, and the plasma is separated from the red blood cells, white blood cells, and platelets.
Serum is made to measure the amount of protein albumin in the blood. When the kidney begins to fail, albumin begins to leak into the urine. The serum test helps diagnose liver and kidney abnormalities.
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